Distribution- Widely distributed in the body.35% bound to the plasma proteins.
Metabolism- Metabolized by reversible pH dependant hydrolysis of its lactone moiety (active part) to inactive hydroxyl acid form. A small portion is metabolized in the liver to active N-demethyl topotecan.
Excretion- Excreted via bile and urine (20-60%).
3. Lowered resistance to infection
4. Bruising or unusual bleeding
7. Sore in mouth
8. Taste changes
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
17. Lower back or side pain
18. Painful or difficult urination
19. Pinpoint red spot on skin
20. Slurred speech
21. Swelling on leg or lower leg
22. Shortness of breath
23. Bloody vomiting
24. Thinned or brittle hair
25. Mouth blistering
30. Chest pain
34. Intestinal obstruction
37. Elevations of liver enzymes
2. Severe bone marrow suppression
2. Lung cancer
3. Chronic myelomonocytic leukemia (CMML)
4. Myelodysplastic syndrome (MDS)
6. Multiple myeloma
8. Pancreatic cancer
10. Ewing`s sarcoma
G-CSF: Coadministration of G-CSF and topotecan may prolong duration of neutropenia. If G-CSF has to be used, it should be started only on day 6 of the course i.e., 24 hr. after completion treatment with topotecan.
Ovary cancer: 1.5mg/metre square/day over 30 minutes for 5 consecutive days, starting on day 1 of a 21 day cycle -
Lung cancer: 1.5mg/metre square over 30 minutes daily for 5 consecutive days. Then follows the treatment for 21 days after 16 days rest
Home Delivery for Topotecan in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including topotecan.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for topotecan and other medicines and health products. Home delivery services for topotecan may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take topotecan only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for topotecan before they complete the sale. You can get this information while placing the order for topotecan with the pharmacy.
Topotecan is a generic medicine name and there are several brands available for it. Some of the brands for topotecan might be better known than topotecan itself. If the pharmacy that's willing to deliver medicines to your home doesn't have topotecan in stock, you can ask for one of the branded alternatives for topotecan.