Anastrozole Pharmacology


About Anastrozole
Non-steroidal Aromatase Inhibitor, Antineoplastic.
Mechanism of Action of Anastrozole
This non-steroid aromatase inhibitors prevents the formation of estrogens from androgens by binding to the heme portion of cytochrome P450 unit of aromatase enzyme (which catalyze the formation of estrogens from androgens) reversibly and competitively. This reduces the estrogens level in the body and also growth of tumors associated with it.
Pharmacokinets of Anastrozole
Absorption- Absorbed rapidly and completely after oral administration
Distribution- Widely distributed in the body.40% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites by N-dealkylation, hydroxylation and glucoronidation. Triazole, hydroxy anastrozole and glucoronide are its inactive metabolites.
Excretion -Excreted via urine (11% as parent drug and 60% as its metabolites) and bile
Onset of Action for Anastrozole
Below 24hrs
Duration of Action for Anastrozole
Below 6 hrs
Half Life of Anastrozole
Its plasma half life is 50 hours.
Side Effects of Anastrozole
1. Flu-like symptoms
2. Weakness
3. Headache
4. Flushing
5. Sweating
6. Nausea
7. Vomiting
8. Loss of appetite
9. Constipation
10. Diarrhea
11. Heart burn
12.Weight gain
13. Joint pain
14. Bone pain
15. Muscle pain
16. Mood changes
17. Depression
18. Nervousness
19. Dizziness
20. Vaginal bleeding
21. Cough
22 Burning or tingling feeling
23. Dry mouth
24. Hair thinning
25. Chest pain
26. Sore throat
27. Chills
28. Swollen gland
29. Difficulty, painful and urgent urination
30. Blurred vision
31. Tachycardia
32. Breast pain
33. New lumps or masses in the breast or other parts of the body
34. Blisters on skin
35. Hives
36. Rash
37. Difficulty falling asleep or staying
38. Leucopenia
39. Thrombophlebitis
40. Abnormal liver enzyme values
Contra-indications of Anastrozole
1. Hypersensitivity to the drug or its ingredients
2. Premenopausal woman
Special Precautions while taking Anastrozole
Hepatic failure
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Anastrozole
1. Breast cancer in post menopausal woman with disease progression following tamoxifen therapy
2. Prostate hyperplasia
3. Gynecomastia
4. Hypogonadism
Interactions for Anastrozole
Oestrogen: diminish its pharmacologic action.
Tamoxifene: It decreases plasma concentration of Anastrazole
Typical Dosage for Anastrozole
Advanced breast cancer in post menopausal woman: 1mg/day for 5 years
Schedule of Anastrozole
Storage Requirements for Anastrozole
Stored in a tightly closed container at room temperature. Protect from light and excessive heat. Keep out of reach of children
Effects of Missed Dosage of Anastrozole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Anastrozole
Give symptomatic and supportive treatment. Dialysis and induce vomiting if needed. Monitor patient vital signs closely.

Home Delivery for Anastrozole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including anastrozole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for anastrozole and other medicines and health products. Home delivery services for anastrozole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take anastrozole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for anastrozole before they complete the sale. You can get this information while placing the order for anastrozole with the pharmacy.

Anastrozole is a generic medicine name and there are several brands available for it. Some of the brands for anastrozole might be better known than anastrozole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have anastrozole in stock, you can ask for one of the branded alternatives for anastrozole.