Methyl Prednisolone Pharmacology

Methyl Prednisolone

About Methyl Prednisolone
A synthetic Systemic glucocorticoid, Antiinflammatory(steroidal), Antiasthmatic, immunosuppressant.
Mechanism of Action of Methyl Prednisolone
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction
Antivertigo action: Methyl Prednisolone suppresses intralabyrinthine edema due to viral infection or other causes.
Pharmacokinets of Methyl Prednisolone
Absorption: Well absorbed orally, Distribution: Drug is rapidly removed from blood and distributed in to muscle, liver, kidney, skin, and intestine. It crosses the placenta and also secreted in breast milk, Metabolism: Metabolized in liver in to inactive metabolites by glucuronide and sulfate conjugation. Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.
Onset of Action for Methyl Prednisolone
Duration of Action for Methyl Prednisolone
30 to 36hours
Half Life of Methyl Prednisolone
18 to 36hours
Side Effects of Methyl Prednisolone
1.Susceptibility to infection
2.Peptic ulcer
7.Atrophy of adrenal cortex(on prolonged therapy)
8.Suppression of adrenocorticotropic hormone
9.Cushing`s syndrome
10.Inhibition of growth in children
12.Behavioral disturbances
13.Thromboembolic disorders
17.Muscle wasting
18.Gastrointestinal discomfort
19.Increased appetite
20.Delayed wound healing
25.Heart failure
27.Posterior sub capsular cataract
29.Sodium and fluid retention
30.Hypo kalaemia
31.Increased intracranial pressure
Contra-indications of Methyl Prednisolone
1.Hypersensitivity to the drug
2.Peptic ulcer
3.Systemic Infections
4.Fungal infections
5.Live vaccines
Special Precautions while taking Methyl Prednisolone
1.Avoid sudden discontinuation of the drug
2.Monitor vital parameters, therapeutic response and adjust the dosage
3.Use lower dosages as much as possible
6.Ocular herpes simplex
7.Primary glaucoma
8.Peptic ulcer
9.Primary psychosis and psychoneurosis
10.Recent myocardial infarction
11.Heart failure
12.Diabetes mellitus
18.Myasthenia gravis
19.Renal impairment
20.Hepatic impairment
21.Non specific Ulcerative colitis
23.Recent intestinal anastomosis
25.Thromboembolic disorders
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Neonates: Contraindicated
Indications for Methyl Prednisolone
1.Allergic conditions
3.Inflammatory conditions
4.Multiple sclerosis
5.Rheumatic disorders
6.Autoimmune diseases
11.Dermatological conditions
12.Ulcerative colitis
13.Crohn`s disease
14.Stevens-Johnson syndrome
15.Aspiration of gastric content
16.Acute gout

Interactions for Methyl Prednisolone
Typical Dosage for Methyl Prednisolone
Oral: Initially 4 to 48mg/day depending up on the severity of the condition. Then adjust the dosage based on patient`s response.
Vertigo: Initial dose: 40 - 80 mg / day for 4 - 5 days, followed by 20 mg / day fro 4 days.
Multiple sclerosis:200mg/day for one week; followed by 80mg every other day for one month.
Inflammation: 2 to 60mg/day in four divided doses depending up on the severity of the condition and patient`s response.
Allergic condition, Asthma, and Dermatological conditions: 40 to 120mg/day depending up on the severity of the condition and patient`s response.
Intralesional injection: 4 to 80mg depending up on the size of the lesion and severity of the condition.
I.V. or I.M.:
Allergic conditions, Ulcerative colitis, Crohn`s disease, Stevens-Johnson syndrome, Multiple sclerosis, Aspiration of gastric content, Transplantation, Cerebral oedema associated with tumor:
Starts with 10 to 500mg I.M. or slow I.V. infusion over half an hour; depending up on the severity of the condition. In transplant patients up to 1g/day, In multiple sclerosis 1g/day up to 3 days.

Children: 0.5mg/kg/day to 30mg/kg/day depending up on the disease type and severity of the condition.
Transplantation: 10 to 20mg/kg/day for 3days.
Asthma: 1 to 4mg/kg/day for 1 to 3 days.
Vertigo : 2 to 4mg/kg/day in 4 to 6 divided doses.
Schedule of Methyl Prednisolone
Storage Requirements for Methyl Prednisolone
Store at room temperature in a well closed container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Methyl Prednisolone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Methyl Prednisolone
Provide symptomatic treatment and supportive measures.

Home Delivery for Methyl Prednisolone in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for methyl prednisolone and other medicines and health products. Home delivery services for methyl prednisolone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take methyl prednisolone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for methyl prednisolone before they complete the sale. You can get this information while placing the order for methyl prednisolone with the pharmacy.

Methyl Prednisolone is a generic medicine name and there are several brands available for it. Some of the brands for methyl prednisolone might be better known than methyl prednisolone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have methyl prednisolone in stock, you can ask for one of the branded alternatives for methyl prednisolone.