Methyl Prednisolone Pharmacology
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction
Antivertigo action: Methyl Prednisolone suppresses intralabyrinthine edema due to viral infection or other causes.
7.Atrophy of adrenal cortex(on prolonged therapy)
8.Suppression of adrenocorticotropic hormone
10.Inhibition of growth in children
20.Delayed wound healing
27.Posterior sub capsular cataract
29.Sodium and fluid retention
31.Increased intracranial pressure
2.Monitor vital parameters, therapeutic response and adjust the dosage
3.Use lower dosages as much as possible
6.Ocular herpes simplex
9.Primary psychosis and psychoneurosis
10.Recent myocardial infarction
21.Non specific Ulcerative colitis
23.Recent intestinal anastomosis
15.Aspiration of gastric content
Vertigo: Initial dose: 40 - 80 mg / day for 4 - 5 days, followed by 20 mg / day fro 4 days.
Multiple sclerosis:200mg/day for one week; followed by 80mg every other day for one month.
Inflammation: 2 to 60mg/day in four divided doses depending up on the severity of the condition and patient`s response.
Allergic condition, Asthma, and Dermatological conditions: 40 to 120mg/day depending up on the severity of the condition and patient`s response.
Intralesional injection: 4 to 80mg depending up on the size of the lesion and severity of the condition.
I.V. or I.M.:
Allergic conditions, Ulcerative colitis, Crohn`s disease, Stevens-Johnson syndrome, Multiple sclerosis, Aspiration of gastric content, Transplantation, Cerebral oedema associated with tumor:
Starts with 10 to 500mg I.M. or slow I.V. infusion over half an hour; depending up on the severity of the condition. In transplant patients up to 1g/day, In multiple sclerosis 1g/day up to 3 days.
Children: 0.5mg/kg/day to 30mg/kg/day depending up on the disease type and severity of the condition.
Transplantation: 10 to 20mg/kg/day for 3days.
Asthma: 1 to 4mg/kg/day for 1 to 3 days.
Vertigo : 2 to 4mg/kg/day in 4 to 6 divided doses.
Home Delivery for Methyl Prednisolone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including methyl prednisolone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for methyl prednisolone and other medicines and health products. Home delivery services for methyl prednisolone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take methyl prednisolone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for methyl prednisolone before they complete the sale. You can get this information while placing the order for methyl prednisolone with the pharmacy.
Methyl Prednisolone is a generic medicine name and there are several brands available for it. Some of the brands for methyl prednisolone might be better known than methyl prednisolone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have methyl prednisolone in stock, you can ask for one of the branded alternatives for methyl prednisolone.