Propofol Pharmacology


About Propofol
A short-acting, intravenous hypnotic, General Anesthetia(Intravenous induction agent).
Mechanism of Action of Propofol
It excites inhibitory and inhibits excitatory synapsis by binding ligand-gated ion channels specially post-synaptic GABA receptors. It cause CNS depression and calcium channel mediated cardiac depression.
Pharmacokinets of Propofol
Distribution - It is rapidly and extensively distributed in the body. It crosses the blood-brain barrier quickly, and its short duration of action is due to rapid redistribution from the CNS to other tissues.95 to 99% bound to the plasma proteins.
Metabolism- It undergo hepatic glucoronidation to inactive metabolites.
Excretion - Excreted through urine.
Onset of Action for Propofol
< 1 minute
Duration of Action for Propofol
6-10 minutes
Half Life of Propofol
3 to 12 hours
Side Effects of Propofol
1. Twitching or jerking
2. Clonic movements
3. Hypotension
4. Asystole (rare)
5. Pain on injection
6. Post-operative nausea / vomiting
7. Hiccup
8. Ophthalmoplegia
9. Rash
10. Anaphylaxis
Contra-indications of Propofol
1. Hypersensitivity to drug or any other ingredients of it
2. Obstetrical procedures
3. Increased intracranial pressure
Special Precautions while taking Propofol
1. Hypovolaemia
2. Epilepsy
3. Dyslipidaemia
4. Increased intracranial pressure
5. ECT
6. Concurrent medication
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Propofol
1. Induction/maintenance of anesthesia
2. Conscious sedation
Interactions for Propofol
Opioids, muscle relaxants / neuromuscular blockers: Increased anaesthesia, increased respiratory depression (opioids), increased neuromuscular blockade.
Midazolam, thiopental, fentanyl: Increased hypnosis.
Nitrous oxide, halothane, isoflurane: Decrease dose.
Typical Dosage for Propofol
Induction- 2 - 2.5 mg/kg q 10 seconds until induction onset.
Maintenance dose: Infusion- 100-200 mcg/kg/min.
Conscious Sedation- 5 mcg /kg /min for at least 5 minutes.
It may increase by 5-10 mcg/kg/min every 5-10 minutes until desired level of sedation achieved.
Over 3 years: 2.5 - 3.5 mg/kg over 20 seconds.
Maintenance dose:Infusion: over 3 years: 125 - 300 mcg /kg /min.

Schedule of Propofol
Storage Requirements for Propofol
Effects of Missed Dosage of Propofol
Effects of Overdose of Propofol
Give symptomatic and supportive treatment. Supportive treatment include artificial respiration, administration of fluid, pressor agents, and anticholinergic as indicated.

Home Delivery for Propofol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including propofol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for propofol and other medicines and health products. Home delivery services for propofol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take propofol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for propofol before they complete the sale. You can get this information while placing the order for propofol with the pharmacy.

Propofol is a generic medicine name and there are several brands available for it. Some of the brands for propofol might be better known than propofol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have propofol in stock, you can ask for one of the branded alternatives for propofol.