Imipramine Pharmacology


About Imipramine
Tricyclic Antidepressant (Tertiary Amine) , dibenzazepine derivative, Antidepressant, migraine prophylatic.
Mechanism of Action of Imipramine
Imipramine acts by inhibiting the re-uptake of Noradrenaline and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitters in the synaptic cleft and produces antidepressant effect. Imipramine also has anticholinergic activity.
It is also useful in migraine prophylaxis. The monoamine uptake blocking property is related to migraine prophylactic activity. These are suited for patient with depression.

Pharmacokinets of Imipramine
Absorption: Imipramine is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Imipramine is metabolised in the liver to the active metabolite Desipramine.
Excretion: Drug is excreted mainly through urine.
Onset of Action for Imipramine
3 weeks
Duration of Action for Imipramine
Up to 6 weeks
Half Life of Imipramine
12 - 16 hours
Side Effects of Imipramine
1. Dryness of mouth
2. Constipation
3. Difficulty in accommodation
4. Tachycardia
5. Difficulty in micturition
6. Impotence
7. Delayed ejaculation
8. Dizziness
9. Lethargy
10. Headache
11. Feeling of tiredness
12. Sedation
13. Tremor
14. Hyper-reflexia
15. Urticaria
16. Rash
17. Pruritis
18. Photosensitivity
19. Hypotension
20. Cardiomyopathy
21. Cholestatic jaundice
22. Edema
23. Agranulocytosis
24. Galactorrhoea
25. Gynaecomastia
26. Anorexia
Contra-indications of Imipramine
1. Hypersensitivity to Imipramine
2. Myocardial infarction
3. Patient on MAOI therapy
Special Precautions while taking Imipramine
1. Renal impairment
2. Hepatic impairment
3. Cardiac arrhythmia
4. Myocardial infarction
5. Tachycardia
6. Heart failure
7. Strokes
8. Angle closure glaucoma
9. History of urine retention
10. Increased intraocular pressure
11. Hyperthyroidism
12. Patient receiving thyroid medications
13. Patient at risk for suicide,
14. Slowly withdraw the drug with caution
15. Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 6 years: Contraindicated
Indications for Imipramine
1. Depressive illness
2. Nocturnal enuresis in children above 5 years
3. Migraine prophylaxis
Interactions for Imipramine
Anticholinergics: Enhanced effect of anticholinergics may occur.
Barbiturates: Serum level of imipramine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of imipramine.
Levodopa: Its bioavailability is reduced, hypertensive episodes.
MAOIs, Furazolidone: Seizures, sweating, coma, hyperexcitability, hyperthermia, tachycardia, mydriasis, confusion, DIC (Disseminated Intravascular Coagulation) and death.
Oral Contraceptives and Phenothiazines : Increase plasma levels of imipramine.
Smoking : Increases metabolic biotransformation.
Alcohol : Sedative effect of alcohol potentiated.
Typical Dosage for Imipramine
Adult: 25 mg 3 times a day dose can be gradually increased up to 200 mg / day.
Maximum daily dose: 300 mg
Children :
Nocturnal enuresis in children above 5 years: 25 mg/ day to be taken 1 hour before bed time. If satisfactory response does not occur then gradually increases the dose up to 75 mg / day.
Maximum dose: 5 mg / kg / day

Schedule of Imipramine
Storage Requirements for Imipramine
Store at 15 - 30 degree C. Keep out of the reach of children
Effects of Missed Dosage of Imipramine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
If the missed dose is taken only at night then skip the missed dose.
Effects of Overdose of Imipramine
Give supportive measures and treatment. Remove the drug from the body by inducing emesis and gastric lavage. Activated charcoal can be given to reduce the absorption of the drug. Seizure can be treated with Diazepam or Phenytoin, arrhythmia with Lidocaine, and acidosis with Sodium bicarbonate

Home Delivery for Imipramine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including imipramine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for imipramine and other medicines and health products. Home delivery services for imipramine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take imipramine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for imipramine before they complete the sale. You can get this information while placing the order for imipramine with the pharmacy.

Imipramine is a generic medicine name and there are several brands available for it. Some of the brands for imipramine might be better known than imipramine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have imipramine in stock, you can ask for one of the branded alternatives for imipramine.