Erythropoietin Pharmacology


About Erythropoietin
A glycoprotein hormone produced by kidney, Colony Stimulating Factor, Erythropoiesis-stimulating agents, antianemic agent.
Mechanism of Action of Erythropoietin
It induces erythropoiesis in a dose dependent manner by binding to specific receptors on target cell surface and alters phosphorylation of intracellular proteins. It acts on erythroid marrow stimulates proliferation of colony forming cells of the erythroid series. It induces haemoglobin formation, erythroblast maturation and releases reticulocytes in circulation.
Pharmacokinets of Erythropoietin
Absorption: It is administered intravenously or subcutaneously.
Onset of Action for Erythropoietin
Duration of Action for Erythropoietin
Half Life of Erythropoietin
Side Effects of Erythropoietin
1. Exacerbate hypertension
2. Exacerbate seizures
3. Renal impairment
4. Hypercalcaemia
5. Arrhythmia
6. Elevated liver enzymes
7. Metalic taste
Contra-indications of Erythropoietin
1. Hypersensitivity to the drug or mammalian cell products or albumin
2. In patients with uncontrolled hypertension
Special Precautions while taking Erythropoietin
1.Haematocrit should be determined once each week to measure the initial response.
2.Blood pressure must be monitored closely throughout treatment to help titrate the dose.
3.For optimal response to therapy adequate stores of iron are required. The response to therapy is blunted in patients of iron defeciency. If hypertensive encephalopathy occurs, treatement is stopped.
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Erythropoietin
1. Anaemia associated with chronic renal failure
2. Anaemia related to cancer chemotherapy
3. Anaemia associated with Zidovudine therapy in AIDS patients
Interactions for Erythropoietin
Typical Dosage for Erythropoietin
I.V.: Starts with 25 to 50i.u./kg over 1 to 2 minutes; thrice weekly. Increases the dosage in increments of 25i.u./kg at intervals of four weeks based on patient`s response.
Maintenance dosage is individualized; usually Maintenance dosage weekly is; 100 to 300i.u./kg in two to three injections.
Schedule of Erythropoietin
Storage Requirements for Erythropoietin
Store at a temperature range of 15 to 30 degree C.
Effects of Missed Dosage of Erythropoietin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Erythropoietin
Give supportive measures and symptomatic treatment.

Home Delivery for Erythropoietin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including erythropoietin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for erythropoietin and other medicines and health products. Home delivery services for erythropoietin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take erythropoietin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for erythropoietin before they complete the sale. You can get this information while placing the order for erythropoietin with the pharmacy.

Erythropoietin is a generic medicine name and there are several brands available for it. Some of the brands for erythropoietin might be better known than erythropoietin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have erythropoietin in stock, you can ask for one of the branded alternatives for erythropoietin.