Ropivacaine Pharmacology


About Ropivacaine
Amide type local anaesthetics
Mechanism of Action of Ropivacaine
Ropivacaine blocks both initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, resulting in inhibition of depolarisation with resultant blockade of conduction
Pharmacokinets of Ropivacaine
Absorption: Absorbed after parenteral administration
Distribution: 94% bound to plasma proteins
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for Ropivacaine
3 to 5 minute
Duration of Action for Ropivacaine
3 to 15 hs
Half Life of Ropivacaine
1.6 to 6 hrs
Side Effects of Ropivacaine
3.Blurred vision
4.Nausea and Vomiting
5.Muscle twitching
Contra-indications of Ropivacaine
2.Complete heart block
3.Severe hypotension Altered coagulation status

Special Precautions while taking Ropivacaine
1.Liver damage
2.Impaired respiratory function
3.Impaired cardiac conduction
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Ropivacaine
1.Surgical anaesthesia
2.Acute pain
Interactions for Ropivacaine
Itraconazole, ketoconazole or clarithromycin may reduce clearance of ropivacaine
Increased metabolism when used with rifampicin
Clearance is inhibited when used with fluvoxamine or ciprofloxacin
Increased risk of toxicity when used with other local anaesthetics
Typical Dosage for Ropivacaine
Surgical anaesthesia:
Adult: Lumbar epidural block: 75-150 mg (15-30 ml) as a 0.5% solution or 0.75 % or 1 %
Caesarean section: 100-150 mg (20-30 ml) as a 0.5% solution or 0.75 %
Thoracic epidural block to establish a block for postoperative pain relief: 25-75 mg (5-15 ml) as a 0.5% solution or 0.75 %
Peripheral nerve block: 175-250 mg (35-50 ml) as a 0.5% solution or 0.75 %
Infiltration anesthesia and field block: Up to 200 mg (40 ml) as a 0.5% or 0.75 %
Child: Management of pre- and postoperative pain: ?1 yr: Caudal epidural block: (as a 0.2% solution) 2 mg/kg (1 ml/kg
Acute pain: Lumbar epidural block: (as a 0.2% solution) 20-40 mg (10-20 ml) as an initial bolus followed by 20-30 mg (10-15 ml) at intervals of ?30 min
Thoracic epidural block: (as a 0.2% solution) 12-28 mg/hr (6-14 ml/hr) as a continuous infusion.
Infiltration anesthesia: 2-200 mg (1-100 ml) as a 0.2% or 0.5 %
Schedule of Ropivacaine
Storage Requirements for Ropivacaine
Store at room temperature in a well closed container. Do not freeze. Keep out of the reach of children
Effects of Missed Dosage of Ropivacaine
Effects of Overdose of Ropivacaine

Home Delivery for Ropivacaine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ropivacaine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ropivacaine and other medicines and health products. Home delivery services for ropivacaine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ropivacaine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ropivacaine before they complete the sale. You can get this information while placing the order for ropivacaine with the pharmacy.

Ropivacaine is a generic medicine name and there are several brands available for it. Some of the brands for ropivacaine might be better known than ropivacaine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ropivacaine in stock, you can ask for one of the branded alternatives for ropivacaine.