Elimination: Biliary excretion; less than 3% is recovered in urine.
4.Runny nose, sore throat, and other cold symptoms
2.Coadministration of cyclosporine or glyburide
2.Bosentan use requires hematocrit monitoring due to potential onset of anemia.
3.Hormone-based contraception is not possible in women taking Bosentan, due to a pharmacokinetic a interaction.
4.This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such
2.Cyclosporine :Bosentan trough concentrations may be increased, while cyclosporine plasma levels may be decreased; coadministration is contraindicated.
3.Glyburide :Plasma concentrations of both glyburide and bosentan may be decreased; coadministration is contraindicated.
4.HMG-CoA reductase inhibitors (eg, atorvastatin, lovastatin, simvastatin) :Plasma concentrations of simvastatin and its metabolite may be decreased when coadministered with bosentan. Bosentan is also expected to reduce plasma concentrations of other HMG-CoA reductase inhibitors metabolized by CYP3A4 (ie, atorvastatin, lovastatin). Monitor cholesterol levels and adjust the HMG-CoA reductase inhibitor dose accordingly.
5.Hormonal contraceptives:Plasma concentrations may be reduced by bosentan, decreasing the effectiveness. Women should not rely on hormonal contraception alone when taking bosentan.
6.Ketoconazole :Plasma concentrations of bosentan may be increased. No dosage adjustment is necessary
7.Phosphodiesterase type 5 inhibitors (eg, sildenafil) :Coadministration may elevate bosentan plasma concentrations, increasing the pharmacologic effects and risk of toxicity. Phosphodiesterase type 5 inhibitor concentrations may be reduced, decreasing the pharmacologic effects. Coadminister these agents with caution
8.Rifampin :Coadministration may increase bosentan trough concentrations after the first concomitant dose and decrease bosentan trough concentrations at steady state
9.Ritonavir-containing regimens :Coadministration may increase bosentan trough concentrations. In patients receiving ritonavir for at least 10 days, start bosentan at 62.5 mg once daily or every other day based on tolerability. In patients receiving bosentan, stop bosentan at least 36 h before starting ritonavir. At least 10 days after starting ritonavir, resume bosentan at 62.5 mg once daily or every other day based upon tolerability.
10.Warfarin :Warfarin plasma concentrations may be decreased by bosentan. Because warfarin has a narrow therapeutic index, monitor coagulation parameters and adjust the warfarin dose as needed
PO 62.5 mg twice daily for 4 wk, then increase to maintenance dosage of 125 mg twice daily. In patients with a body weight less than 40 kg, the recommended maintenance dosage is 62.5 mg twice daily.
Dosage adjustments are necessary in patients developing aminotransferase abnormalities
Symptoms of overdose may include:
Home Delivery for Bosentan in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including bosentan.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for bosentan and other medicines and health products. Home delivery services for bosentan may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take bosentan only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for bosentan before they complete the sale. You can get this information while placing the order for bosentan with the pharmacy.
Bosentan is a generic medicine name and there are several brands available for it. Some of the brands for bosentan might be better known than bosentan itself. If the pharmacy that's willing to deliver medicines to your home doesn't have bosentan in stock, you can ask for one of the branded alternatives for bosentan.