Cervarix Pharmacology


About Cervarix
Human papillomavirus vaccine type 16 L1protein 20 mcg, human papillomavirus vaccine type 18 L1protein 20 mcg/0.5 mL(ASO4 adjuvanted).
Mechanism of Action of Cervarix
Human Papillomavirus (HPV) type 16 and 18 cause about 70% of cervical cancer. HPV bivalent (types 16 and 18) vaccine is a non-infectious vaccine produced by recombinant technology, which contains virus-like particles (VLP) of the major capsid L1 protein of oncogenic HPV types 16 and 18. Efficacy of vaccine may be mediated by the production of IgG neutralizing antibodies against the HPV-L1 capsid proteins.
Pharmacokinets of Cervarix
Onset of Action for Cervarix
Duration of Action for Cervarix
Half Life of Cervarix
Side Effects of Cervarix
1.Pain, redness and swelling at the injection site
7.GI symptoms (e.g. nausea, vomiting, diarrhea, abdominal pain)
11.Potentially Fatal: Hypersensitivity reactions including anaphylactic and anaphylactoid reactions, angioedema.
Contra-indications of Cervarix
2.Postpone admin in patient suffering from an acute febrile illness.
Special Precautions while taking Cervarix
1.Observe patient for 15 min after admin as syncope, sometimes accompanied by transient tonic clonic movements and other seizure-like activity may occur during recovery.
2.Caution in patients with thrombocytopenia or other coagulation disorders as IM admin can cause bleeding.
3.Not to be administered by IV, SC, or intradermal route.
4.Immunocompromised individuals may have diminished immune response to the vaccine.
5.As vaccination will not provide protection against every HPV infection or existing HPV infections, routine cervical screening should still be performed.
Pregnancy Related Information
Should be postponed until after the pregnancy is over.
Old Age Related Information
Breast Feeding Related Information
Use with caution
Children Related Information
Not recommended for use in girls below 10 yr of age.
Indications for Cervarix
(Female only)
1.Prevention of cervical cancer caused by HPV types 16 and 18
2.Prevention of incident and persistent infections caused by HPV types 16 and 18
3.Prevention of cytological abnormalities including atypical squamous cells of undetermined significance (ASC-US) caused by HPV types 16 and 18
4.Prevention of cervical intraepithelial neoplasia (CIN), CIN 1 and pre-cancerous lesions (CIN 2 and 3)caused by HPV types 16 and 18
5.Prevention of adenocarcinoma in situ caused by HPV types 16 and 18
Interactions for Cervarix
Immunosuppressive therapies e.g. irradiation, cytotoxic drugs and corticorsteroids may reduce a patient's immune response to the vaccine.
Typical Dosage for Cervarix
Adult: Females 10-25 yr (or between 10-45 yr in some countries): 3 doses of 0.5 mL each (Cervarix?) given at 0, 1 and 6 mth, preferably administered into deltoid muscle.
Schedule of Cervarix
Storage Requirements for Cervarix
Intramuscular: Store refrigerated at 2-8?C; do not freeze; discard if frozen.
Effects of Missed Dosage of Cervarix
1.Contact your doctor if you will miss an Cervarix booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.
2.Be sure you receive all recommended doses of this vaccine. If you do not receive the full series of vaccines, you may not be fully protected against the disease.
Effects of Overdose of Cervarix

Home Delivery for Cervarix in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cervarix.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cervarix and other medicines and health products. Home delivery services for cervarix may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cervarix only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cervarix before they complete the sale. You can get this information while placing the order for cervarix with the pharmacy.

Cervarix is a generic medicine name and there are several brands available for it. Some of the brands for cervarix might be better known than cervarix itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cervarix in stock, you can ask for one of the branded alternatives for cervarix.