Eflornithine Pharmacology


About Eflornithine
Mechanism of Action of Eflornithine
Sleeping sickness treatment:Eflornithine appears to kill trypanosomes by acting as a suicide inhibitor of the enzyme ornithine decarboxylase. This enzyme regulates cell division by catalysing the first step in polyamine biosynthesis. As the inhibitor has a low half-life in humans, it is broken down rapidly while the parasite cannot metabolise it quickly enough. This means that it preferentially harms the parasite.
Pharmacokinets of Eflornithine
1.Absorption:Well absorbed after oral administration; bioavailability approximately 50%. {04} {07}
2.Distribution:Crosses the blood-brain barrier, with cerebrospinal fluid (CSF) concentrations reaching 6 to 51% of corresponding blood concentrations:Protein binding:No significant plasma protein binding.
3.Elimination:Renal; approximately 80% excreted unchanged in the urine within 24 hours.
Onset of Action for Eflornithine
Duration of Action for Eflornithine
Half Life of Eflornithine
3.2 to 3.6 hours.
Side Effects of Eflornithine
1.Hematologic abnormalities
4.Reversible hearing loss has occurred in 30?70% of patients receiving long-term therapy (more than 4?8 weeks of therapy or a total dose of >300 grams):high-frequency hearing is lost first, followed by middle- and low-frequency hearing. Because treatment for African trypanosomiasis is short-term, patients are unlikely to experience hearing loss.
Contra-indications of Eflornithine
1.Eighth-cranial-nerve impairment
2.Pre-existing Hematologic abnormalities
3.Renal function impairment
Special Precautions while taking Eflornithine
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Not recommended
Indications for Eflornithine
African trypanosomiasis (sleeping sickness)
Interactions for Eflornithine
May interact with bone marrow depressants and ototoxic medications.
Typical Dosage for Eflornithine
Sleeping sickness treatment:Intravenous infusion, 100 mg per kg of body weight, infused over at least forty-five minutes, every six hours for fourteen days.
Schedule of Eflornithine
Storage Requirements for Eflornithine
Sleeping sickness treatment:Intravenous infusion, 100 mg per kg of body weight, infused over at least forty-five minutes, every six hours for fourteen days.
Effects of Missed Dosage of Eflornithine
Effects of Overdose of Eflornithine

Home Delivery for Eflornithine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including eflornithine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for eflornithine and other medicines and health products. Home delivery services for eflornithine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take eflornithine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for eflornithine before they complete the sale. You can get this information while placing the order for eflornithine with the pharmacy.

Eflornithine is a generic medicine name and there are several brands available for it. Some of the brands for eflornithine might be better known than eflornithine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have eflornithine in stock, you can ask for one of the branded alternatives for eflornithine.