Eperisone Pharmacology


About Eperisone
Antispasmodic,muscle relaxant.
Mechanism of Action of Eperisone
Skeletal Muscle Relaxation: Inhibition of Experimentally Induced Muscle Rigidity: Eperisone HCl suppresses intercollicular section-induced decerebrate rigidity (?-rigidity) and ischemic decerebrate rigidity (?-rigidity) in rats dose-dependently.
Suppression of Spinal Reflexes: In spinal cats, eperisone HCl suppresses mono- and polysynaptic reflex potentials induced through spinal nerve efferent root stimulation to a similar degree.
Reduction of Muscle Spindle Sensitivity via ?-Motor Neurons: Eperisone HCl suppresses the activity of afferent nerve fibers (Ia fibers) from human muscle spindles at 20 min after administration. Eperisone HCl suppresses the spontaneous discharge of ?-motor neurons, but does not act directly on muscle spindles in animals. Accordingly, eperisone HCl reduces muscle spindle sensitivity via the ?-motor neurons.
Vasodilatation and Augmentation of Blood Flow: Vasodilatory Action: Eperisone HCl dilates the blood vessels due to Ca2+-antagonistic action (in guinea pigs) on the vascular smooth muscle and muscular sympatholytic actions (in humans).
Augmentation of Blood Flow: Eperisone HCl increases the volume of blood flow in skin, muscle, external and internal carotid arteries and vertebral arteries in humans, monkeys and dogs.
Analgesic Action and Inhibition of the Pain Reflex in the Spinal Cord: When eperisone HCl is perfused into the spinal cord of rats, a tail pinch-induced pain reflex is suppressed, but the reflex returns with the withdrawal of eperisone HCl. This suggests that eperisone HCl possesses an analgesic action at the spinal cord level.
Facilitation of Voluntary Movement: When eperisone HCl is used in the treatment of spastic paralysis in patients with cerebral apoplexy, it improves the cybex torque curve and electromyogram and facilitates voluntary movements eg, extension and flexion of the extremities, without reducing the muscular force.
Pharmacokinets of Eperisone
Onset of Action for Eperisone
Duration of Action for Eperisone
Half Life of Eperisone
1.6 - 1.8 hr.
Side Effects of Eperisone
5.Numbness or trembling in the extremities
6.Hepatic and renal dysfunction
7.Haematological changes
8.Skin rashes
10.GI disturbances
11.Urinary disorders
12.Rarely, shock.
Contra-indications of Eperisone
Eperisone is contraindicated in patients with known hypersensitivity to the drug.
Special Precautions while taking Eperisone
1.Hepatic impairment.
2.May impair ability to drive and operate machines.
Pregnancy Related Information
Not recommended
Old Age Related Information
Reduced dose is recommended, and the patient should be closely monitored for signs of psychological hypofunction during treatment.
Breast Feeding Related Information
Contra indicated
Children Related Information
Not recommended
Paediatric:Not recommended
Indications for Eperisone
1.Spastic paralysis in conditions such as cerebrovascular disease
2.Spastic spinal paralysis
3.Cervical spondylosis
4.Postoperative sequelae (including from cerebrospinal tumour)
5.Sequelae to trauma (e.g. spinal trauma or head injury)
6.Amyotrophic lateral sclerosis
7.Cerebral palsy
8.Spinocerebellar degeneration
9.Spinal vascular diseases and other encephalomyelopathies
10.Cervical syndrome, periarthritis of the shoulder, and lumbago
Interactions for Eperisone
Disturbances in ocular accommodation occurring after the concomitant use of the related drug tolperisone hydrochloride and methocarbamol.avoid concomitant use with these.
Typical Dosage for Eperisone
Adults: 50?150 mg per day, in divided doses, after meals.
Schedule of Eperisone
Storage Requirements for Eperisone
Oral: Store at 15-30?C.
Effects of Missed Dosage of Eperisone
Effects of Overdose of Eperisone

Home Delivery for Eperisone in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for eperisone and other medicines and health products. Home delivery services for eperisone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take eperisone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for eperisone before they complete the sale. You can get this information while placing the order for eperisone with the pharmacy.

Eperisone is a generic medicine name and there are several brands available for it. Some of the brands for eperisone might be better known than eperisone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have eperisone in stock, you can ask for one of the branded alternatives for eperisone.