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- Pharmacology For Loperamide + Lactobacillus
Loperamide + Lactobacillus Pharmacology
Loperamide + Lactobacillus
About Loperamide + LactobacillusN/AMechanism of Action of Loperamide + LactobacillusN/APharmacokinets of Loperamide + LactobacillusN/AOnset of Action for Loperamide + LactobacillusN/ADuration of Action for Loperamide + LactobacillusN/AHalf Life of Loperamide + LactobacillusN/ASide Effects of Loperamide + LactobacillusN/AContra-indications of Loperamide + LactobacillusN/ASpecial Precautions while taking Loperamide + LactobacillusN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Loperamide + LactobacillusAcute and chronic Diarrhea.Interactions for Loperamide + LactobacillusN/ATypical Dosage for Loperamide + LactobacillusN/ASchedule of Loperamide + LactobacillusN/AStorage Requirements for Loperamide + LactobacillusN/AEffects of Missed Dosage of Loperamide + LactobacillusN/AEffects of Overdose of Loperamide + LactobacillusN/ALoperamide
About LoperamideA synthetic piperidine derivative, Opioid, Antidiarrhoeal, Analgesic.Mechanism of Action of LoperamideLoperamide is a mu receptor agonist. It inhibits the release of Acetylcholine on myenteric plexus in the gastrointestinal tract. This results in slowing intestinal motility and reduces peristalsis and increase intestinal transit time. This will results in increased absorption of water from fecal matter. Loperamide also has a direct action on intestinal smooth muscle. It does not have any effect on central nervous system.Pharmacokinets of LoperamideAbsorption: Loperamide is poorly absorbed after oral administration
Distribution: It is widely distributed mainly in protein bound form
Metabolism: Absorbed drug undergoes metabolism in the liver
Excretion: It is excreted mainly in the faeces and small amount in the urine.
Onset of Action for Loperamide1 - 2 hours.Duration of Action for Loperamide1 dayHalf Life of Loperamide7 - 14 hoursSide Effects of Loperamide1.Dry mouth
2.Abdominal pain
3.Nausea
4.Vomiting
5.Gastric discomfort
6.Drowsiness
7.Dizziness
8.Tiredness
9.Constipation
10.Allergic reaction
11.Toxic megacolon
Contra-indications of Loperamide1.Hypersensitivity to Loperamide
2.Severe diarrhoea where inhibition of peristalsis is not desirable
3.Fever
4.Bloody stool diarrhoea
5.Pseudomembranous enterocolitis
Special Precautions while taking Loperamide1.Hepatic impairment
2.Acute ulcerative colitis
3.Crohn`s disease
4.Intestinal stasis
5.Pyloric obstruction
6.Urinary bladder neck obstruction
7.Gastric retentions
8.Use caution while driving vehicle or operating machine or performing activities requiring mental alertness
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 2 years: contraindicated
NEONATES: contraindicated
Indications for Loperamide1.DiarrhoeaInteractions for LoperamideN/ATypical Dosage for LoperamideAdult (Oral): Initial dose: 4 mg followed by 2 mg after each loose motion. Maintenance dose: 6 - 8 mg daily
Maximum dose: 16 mg / day
Children:
2 - 5 years: 3 mg / day in 3 divided doses
6 - 8 years: 4 mg / day in 2 divided doses
8 - 12 years: 6 mg / day in 3 divided doses
Schedule of LoperamideHStorage Requirements for LoperamideStore the drug at 15 - 30 degree C in a tightly closed container. Protect from heat and light.Effects of Missed Dosage of LoperamideDo not apply if it is taken as to control diarrhoea.
If it is taken as a regular schedule then take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of LoperamideGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal. Respiratory depression can be treated with Naloxone. Lactobacillus
About LactobacillusLactic acid bacteria, Probiotic,Antidiarrhoeal.Mechanism of Action of LactobacillusLactobacillus is a probiotic and it is called as friendly bacteria. It is used along with antibiotic in order to restore the body`s natural microbial flora with in the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts. This will alter the intestinal pH and that make the environment hostile for pathogens.Pharmacokinets of LactobacillusAbsorption: It is orally well absorbed after oral administration.
Onset of Action for LactobacillusN/ADuration of Action for LactobacillusN/AHalf Life of LactobacillusN/ASide Effects of Lactobacillus1.Abdominal discomfort
2.Vaginal irritation (when used vaginally)
Contra-indications of Lactobacillus1.Recent bowel surgery
2.Intestinal damage
3.Weakened immune system
Special Precautions while taking LactobacillusPatient on Inulin treatmentPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Use with cautionIndications for Lactobacillus1.Aphthous stomatitis
2.Hypochlorhydria
3.Hepatic encephalopathy
4.Adjuvant to antibiotic therapy
5.Diarrhoea.Interactions for LactobacillusN/ATypical Dosage for LactobacillusAdult: 60 - 150 million spores 3 times daily depending on the severity of infections.
Vaginal bacterial infections: 1- 2 billion bacteria 2 - 3 times daily
Suppositories:
Vaginal infections, cystitis: 1 - 2 suppositories are inserted in to vagina at night for 2 weeks. Each suppository contains 1 - 2 billion lactobacilli
Schedule of LactobacillusN/AStorage Requirements for LactobacillusRefrigerate below 5 degree C.Effects of Missed Dosage of LactobacillusN/AEffects of Overdose of LactobacillusGive supportive measures and symptomatic treatmentHome Delivery for Loperamide + Lactobacillus in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including loperamide + lactobacillus.
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Loperamide + Lactobacillus is a generic medicine name and there are several brands available for it. Some of the brands for loperamide + lactobacillus might be better known than loperamide + lactobacillus itself. If the pharmacy that's willing to deliver medicines to your home doesn't have loperamide + lactobacillus in stock, you can ask for one of the branded alternatives for loperamide + lactobacillus.