Erythromycin Pharmacology


About Erythromycin
Macrolide Antibiotic.
Mechanism of Action of Erythromycin
Erythromycin is a member of macrolide antibiotics. It binds to the 50S sub unit of bacterial ribosome and inhibits they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.
Pharmacokinets of Erythromycin
Absorption: The buffered form of erythromycin is completely absorbed.Distribution: It is widely distributed in the body in protein bound form.Metabolism: small portion undergo metabolism to inactive compound.Excretion: It is primarily excreted through bile and also through urine and breast milk.
Onset of Action for Erythromycin
2 - 4 hour
Duration of Action for Erythromycin
8 - 12 hour
Half Life of Erythromycin
1 - 2 hour
Side Effects of Erythromycin
4.Epigastric pain
8.Super infection
11.Cholestatic jaundice
12.Hearing disturbances (Ototoxicity)
Contra-indications of Erythromycin
1.Hypersensitivity to erythromycin and other macrolide
2.Liver disease
Special Precautions while taking Erythromycin
1.Renal impairment
2.Hepatic dysfunction
4.Heart failure
Pregnancy Related Information
Use with caution.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
Indications for Erythromycin
10.Wound and burn infection
11.Rheumatic fever
13.Urogenital infection
15.Intestinal amoebiasis
16.Skin and soft tissue infections
Interactions for Erythromycin
Anticoagulants: Efficacy enhanced leading to haemorrhages.
Bromocriptine: Efficacy protentiated leading to toxicity.
Carbamazepine: Dangerous toxic side effects requiring resuscitative measures and hospitalisation.
Digoxin: Serum levels of digoxin enhanced, leading to toxicity.
Disopyramide: Increased disopyramide plasma levels leading to arrhythmias.
Ergot Alkaloids: Acute ergotism manifested as peripheral ischaemia.
Methylprednisolone: Decreases methylprednisolone clearance.
Penicillins: Alters efficacy, may be synergistic or antagonist.
Theophylline: Increased serum theophylline levels resulting in toxicity. Decreased serum levels of erythromycin.
Triozolam: Increased CNS depression.
Typical Dosage for Erythromycin
Adult: 250 - 500 mg every 6 hours
Pneumonia: 250 - 500 mg four times daily for 2 - 3 weeks
Diphtheria: 500 mg four times daily for 1 - 2 weeks
Pertusis: 2 g /day in four divided dose for 2 weeks
Chancroid, Urogenital infections: 500 mg every 6 hours for 1 week
Urethritis: 500 mg orally four times a day for 7 days
Children: 30 - 60 mg/kg body weight/day in 4 divided dose
Pnumonia: 50 mg/kg body weight/day in four divided dose for 3 week
Conjunctivitis: 50 mg/ kg body weight/day in four divided dose for 2 week
Schedule of Erythromycin
Storage Requirements for Erythromycin
Store in a cool dark place. Keep away from heat and moisture.
Effects of Missed Dosage of Erythromycin
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.

Effects of Overdose of Erythromycin
Give supportive measures and treatment

Home Delivery for Erythromycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including erythromycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for erythromycin and other medicines and health products. Home delivery services for erythromycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take erythromycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for erythromycin before they complete the sale. You can get this information while placing the order for erythromycin with the pharmacy.

Erythromycin is a generic medicine name and there are several brands available for it. Some of the brands for erythromycin might be better known than erythromycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have erythromycin in stock, you can ask for one of the branded alternatives for erythromycin.