Azithromycin Pharmacology


About Azithromycin
An Azalide, macrolide antibiotic.
Mechanism of Action of Azithromycin
Azithromycin is a member of macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits they: interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Azithromycin is active against both gram positive and gram negative aerobic and anaerobic bacteria
Pharmacokinets of Azithromycin
Absorption: Azithromycin is completely absorbed after oral administration. Distribution: It is widely distributed in the body .Metabolism: It is not metabolized in the body. Excretion: It is primarily excreted through bile and a very small amount excreted through urine.
Onset of Action for Azithromycin
1-2 hours.
Duration of Action for Azithromycin
Half Life of Azithromycin
68 hour
Side Effects of Azithromycin
1. Nausea
4.Epigastric pain
11.Cholestatic jaundice
12.Hearing disturbances

Contra-indications of Azithromycin
1.Hypersensitivity to Azithromycin and other macrolide
Special Precautions while taking Azithromycin
1.Renal impairment
2.Hepatic dysfunction
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution
Indications for Azithromycin
9.Prevention of disseminated Mycobacterium avium complex infection
10.Otitis media
13.Urogenital infection
14.Skin and soft tissue infections
Interactions for Azithromycin
Aluminium & Magnesium containing Antacids: Decrease peak serum levels.
Theophylline: Serum concentration of Theophylline increased.
Warfarin: Anticoagulant effects enhanced.
Digoxin & Cyclosporine: Increase in their serum concentration.
Carbamazepine: Toxicity occurs which may require hospitalization.
Triazolam: Increases serum levels of Triazolam leading to toxicity.
Ergot Alkaloids: Acute ergotism manifested as peripheral ischaemia.
Food: Absorption reduced by as much as 52% (should be taken 1 hr before or 2 hrs after meal).

Typical Dosage for Azithromycin
500 mg once daily for 1 day followed by 250 mg once daily for 4 days.
For the treatment of urethritis and cervicitis: 1 - 2 g as a single dose
Prophylaxis of MAC: 1200 mg once weekly
Chancroid: 1000 mg as a single dose
Children: 10 mg / kg body weight once daily on 1 day followed by 5 mg / kg body weight once daily for 4 days.
Schedule of Azithromycin
Storage Requirements for Azithromycin
Store in a cool dark place. Keep away from heat and moisture.
Effects of Missed Dosage of Azithromycin
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Azithromycin
Give supportive measures and symptomatic treatment

Home Delivery for Azithromycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including azithromycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for azithromycin and other medicines and health products. Home delivery services for azithromycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take azithromycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for azithromycin before they complete the sale. You can get this information while placing the order for azithromycin with the pharmacy.

Azithromycin is a generic medicine name and there are several brands available for it. Some of the brands for azithromycin might be better known than azithromycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have azithromycin in stock, you can ask for one of the branded alternatives for azithromycin.