Minocycline Pharmacology


About Minocycline
A semisynthetic Tetracycline derivative, A broad spectrum antibiotic.
Mechanism of Action of Minocycline
Minocycline is a broad spectrum antibiotic which acts against both gram positive and gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein and by passive diffusion & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals).Minocycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca &Mg and inhibits functioning of various enzymes & ribosome.
Pharmacokinets of Minocycline
Absorption: orally well absorbed, Distribution: widely distributed; shows protein- binding, Metabolism: A portion of drug is metabolized inside the body, Excretion: Primarily excreted through urine. Some drug is present in bile & breast milk
Onset of Action for Minocycline
4-6 hours.
Duration of Action for Minocycline
24 hours.
Half Life of Minocycline
11 to 22 hours
Side Effects of Minocycline
1.Vestibular toxicity
2.Intracranial hypertension
9.Epigastric distress
11.Elevated liver enzymes
12.Discoloration of teeth
13.Esophageal ulceration
14.Skin rashes
18.Retardation of bone growth
Contra-indications of Minocycline
1.Hypersensitivity to the drug or other tetracyclines
2.Hepatic impairment
3.Renal impairment

Special Precautions while taking Minocycline
1.Renal impairment:
2.Hepatic impairment:
3.Sun exposure may leads to phototoxicity

Pregnancy Related Information
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Children Related Information
Neonates: Contraindicated.

Indications for Minocycline
1.Syphilis, Chancroid
2.Granuloma inguinale
4.Respiratory tract infections
5.Pleural effusion
6.Urinogenital tract infections
8.Pelvic inflammatory diseases
11.Gonorrhea in penicillin allergic individuals
13.Rickettsial infections
15.Skin & Soft tissue infections
Interactions for Minocycline
Antacids (aluminium, calcium, zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of minocycline possibly reducing its efficacy.
Anticoagulants: Increase the hypoprothrombinemic effects of anticoagulants.
Cimetidine: Decreases GI absorption may lead to decreased efficacy.
Digoxin: Increased serum levels leading to digoxin toxicity.
Methoxyflurane: Nephrotoxic effects of both increased.
Oral contraception: Breakthrough bleeding; pregnancy may occur.
Penicillins: May interfere with bactericidal action of penicillin.
Food: Some dairy products interfere with absorption of minocycline.

Typical Dosage for Minocycline
Adults: 0.2gm initial dose followed by 0.1gm twice daily or 0.05gm four times daily for a week to two weeks
Acne: 0.05gm once daily to three times daily.
Pleural effusion: 300mg in 50 ml sodium chloride injection
Children (above 8 years of age): Initially 4 mg/kg/day in two divided doses followed by 2mg/kg/day twice daily.
Schedule of Minocycline
Storage Requirements for Minocycline
Store in a cool place.
Effects of Missed Dosage of Minocycline
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Minocycline
Treatment is supportive & symptomatic. Gastric lavage & administration of antacids as soon as possible

Home Delivery for Minocycline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including minocycline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for minocycline and other medicines and health products. Home delivery services for minocycline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take minocycline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for minocycline before they complete the sale. You can get this information while placing the order for minocycline with the pharmacy.

Minocycline is a generic medicine name and there are several brands available for it. Some of the brands for minocycline might be better known than minocycline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have minocycline in stock, you can ask for one of the branded alternatives for minocycline.