Secnidazole Pharmacology


About Secnidazole
A nitroimidazole derivative, Antiprotozoal.
Mechanism of Action of Secnidazole
Secnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which exerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization & strand breakage has been observed.
Pharmacokinets of Secnidazole
Absorption: Well absorbed orally, Distribution: Widely distributed
Metabolism: Metabolized in liver, Excretion: Excreted in urine.
Onset of Action for Secnidazole
Within few hours
Duration of Action for Secnidazole
Below 24 hours
Half Life of Secnidazole
17 to 29 hours
Side Effects of Secnidazole
1. Anorexia,
2. Glossitis,
3. Nausea,
4. Vomiting,
5. Diarrhoea,
6. Fatigue,
7. Dry mouth,
8. Abdominal distress,
9. Headache,
10. Dizziness,
11. Rash,
12. Urticaria,
13. Leucopenia,
Contra-indications of Secnidazole
Hypersensitivity to the drug
Special Precautions while taking Secnidazole
1.Hepatic impairment
2.Alcoholic cirrhosis
3.In obstructive liver diseases
4.Use cautiously along with other hepatotoxic drugs & In visual field changes
5 Avoid alcohol use during therapy
6.Neurological disorders
Pregnancy Related Information
Use with caution, but contra indicated in first trimester
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Secnidazole
3.Trichomonas vaginitis
4.Bacterial vaginosis
Interactions for Secnidazole
Anticoagulants: May potentiate anticoagulant effect of warfarin; increased risk of haemorrhage.
Disulfiram: Antabuse-like effects.
Cimetidine: Half-life of secnidazole is prolonged.
Lithium: Plasma levels of lithium increased leading to toxicity.

Typical Dosage for Secnidazole
Amoebiasis, Trichomoniasis & Giardiasis
Adults: 2gm once only dosage
Children: 30 mg/kg once only
Schedule of Secnidazole
Storage Requirements for Secnidazole
Store in cool dry place.Protect from heat nd light.Keep out of the reach of children.
Effects of Missed Dosage of Secnidazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Secnidazole
Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, administration of activated charcoal & use of cathartics. For controlling seizures diazepam & phenytoin may be used.

Home Delivery for Secnidazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including secnidazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for secnidazole and other medicines and health products. Home delivery services for secnidazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take secnidazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for secnidazole before they complete the sale. You can get this information while placing the order for secnidazole with the pharmacy.

Secnidazole is a generic medicine name and there are several brands available for it. Some of the brands for secnidazole might be better known than secnidazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have secnidazole in stock, you can ask for one of the branded alternatives for secnidazole.