Folate antagonist used in cancer chemotherapy, inhibit Dihydrofolate reductase enzyme and inhibit the conversion of Dihydrofollic acid(DHFA) to Tetrahydrofolic acid (THFA).Leucovorin act as an antidote for folate antagonist.
2 poisoning with. Folic acid antagonist
3.Adjuvant treatment of colorectal cancer
Fluorouracil: Cytotoxic effects of fluorouracil enhanced.
Folic acid antagonists: Should not be co-administered with a folic acid antagonist.
Overdose of folic acid antagonist: Dose is equivalent to the dose of folate antagonistand is given as IM or IV
Leucovorin rescue after Methotrexate chemotherapy: Treatment should be given 24 hours after Methotrexate chemotherapy.
Leucovorin rescue is 10mg/metre square as IV infusion every 6 hours for 10 doses and it can be continued until serum Methotrexate level is less than 5 ?10 to the power of(-8)
Leucovorin is administered as 200 mg/metre square by slow intravenous injection over a minimum of 3 minutes, followed by 5-fluorouracil at 370 mg/metre square by intravenous injection.
2. Leucovorin is administered at 20 mg/metre square by slow intravenous injection over a minimum of 3 minutes, followed by 5-fluorouracil at 425 mg/metre square by intravenous injection.
Folate deficient Megaloblastic anaemias: up to 1 mg/day as IM
Megaloblastic anaemia from congenital enzyme deficiency: 3-6 mg IM /day
Excessive amount of Leucovorin antagonizes the chemotherapeutic effect of folate antagonist
Home Delivery for Leucovorin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including leucovorin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for leucovorin and other medicines and health products. Home delivery services for leucovorin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take leucovorin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for leucovorin before they complete the sale. You can get this information while placing the order for leucovorin with the pharmacy.
Leucovorin is a generic medicine name and there are several brands available for it. Some of the brands for leucovorin might be better known than leucovorin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have leucovorin in stock, you can ask for one of the branded alternatives for leucovorin.