Clopamide Pharmacology

Clopamide

About Clopamide

A piperidine diuretic, sulfamyl, thiazide like diuretics, Anti hypertensive ,diuretic.

Mechanism of Action of Clopamide

It exerts thiazides like diuretic action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+-Cl- symporter and inhibits Na+-Cl- symport at the luminal membrane. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+ and hence used to correct hypocalcaemia. It also reduces glomerular filtration rate. The antihypertensive actions of the drug may be attributable to depletion of sodium and subsequent reduction in plasma volume and a decrease in peripheral resistance. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.

Pharmacokinets of Clopamide

It is absorbed orally.

Onset of Action for Clopamide

1 to 2 hours

Duration of Action for Clopamide

18 to 24 hours

Half Life of Clopamide

N/A

Side Effects of Clopamide

1.Dizziness
2.Headache
3.Nausea
4.Diarrhoea
5.Vomiting
6.Dry mouth
7.Weakness
8.Hypokalaemia
9.Hyponatraemia
10.Elevated levels of glucose, calcium, and lipids
11.Gastro intestinal disturbances
12.Impotence
13.Visual impairment
14.Electrolyte imbalance
15.Postural hypotension
16.Aplastic anaemia
17.Haemolytic anaemia
18.Paraesthesia
19.Photosensitivity
20.Jaundice
21.Ototoxicity

Contra-indications of Clopamide

1.Hyponatraemia
2.Hypokalaemia
3.Renal impairment
4.Hepatic impairment
5.Hypersensitivity to the drug
6.Hypersensitivity to Sulfonamides
7.Hypercalcaemia
8.Anuria
9.Addison`s diseases

Special Precautions while taking Clopamide

1.Gout
2.Diabetes mellitus
3.Renal impairment
4.Hepatic diseases
5.Hyperlipidaemia
6.Ventricular extra systoles
7.Severe heart failure
8.Cirrhosis
9.Fluid and electrolyte imbalance

Pregnancy Related Information

Contraindicated.

Old Age Related Information

Use with caution.

Breast Feeding Related Information

Contraindicated.

Children Related Information

N/A

Indications for Clopamide

1.Hypertension
2.Oedema associated with heart failure
3.Oedema due to renal and hepatic diseases
4.Ascites due to cirrhosis.

Interactions for Clopamide

Anticoagulants & hypoglycemic agents: Efficacy decreased with Clopamide.
Beta-blockers: Efficacy of beta blockers increased.
Frusemide: Diuretic action of frusemide enhanced.
Lithium: Reduces lithium clearance resulting in toxicity, hence its dose should not be reduced.

Typical Dosage for Clopamide

10 to 40mg daily or on alternate days. Increased to 60mg; if required.

Schedule of Clopamide

Storage Requirements for Clopamide

Store at a cool dry place in a well closed container.

Effects of Missed Dosage of Clopamide

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Clopamide

Treatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and support electrolyte balance and blood acidosis. Acidotic state can be corrected by administration of bicarbonate.

Home Delivery for Clopamide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clopamide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clopamide and other medicines and health products. Home delivery services for clopamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clopamide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clopamide before they complete the sale. You can get this information while placing the order for clopamide with the pharmacy.

Clopamide is a generic medicine name and there are several brands available for it. Some of the brands for clopamide might be better known than clopamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clopamide in stock, you can ask for one of the branded alternatives for clopamide.