Isosorbide Dinitrate Pharmacology
It causes preload reduction, slight decrease in after load, and preferential relaxation of larger conducting coronary arteries and is used as an effective drug in the management of both angina and congestive heart failure.
Distribution: Widely distributed in the body.
Metabolism: Metabolized in liver to active metabolites.
Excretion: Excreted mainly through urine.
Oral: 30 minutes
Oral: 5 to 6 hours
Oral: 5 to 6 hours
7. Orthostatic hypotension
9. Sub lingual burning
2. Hypersensitivity to nitrates
3. Severe hypotension
5. Along with phosphodiesterase inhibitors
3. Blood volume depletetion
4. Cerebral haemorrhage
6. Sidenafil causes dangerous potentiation of action hypotension myocardial infarction and death
2. Variant angina
3. Adjunctive treatment of heart failure
4. Esophageal spasm without gastroesophagial reflux.
Aspirin: Increase serum concentrations of nitrates and their actions.
Antihypertensives, TCAs, Phenothiazine, Calcium channel blockers: Marked symptomatic orthostatic hypotension.
Lab Tests: May interfere with the Zlatkis-Zak colour reaction causing a false report of decreased serum cholesterol.
Sublingual form: 2.5 to 10mg. Repeated every 2 to 3 hours during acute phase or every 4 to 6 hours for prophylaxis.
Chewable form: Starts with 5mg test dose and increased up to 10mg as required for acute attack or every 2 to 3 hours for prophylaxis.
Oral form: 10 to 20mg three to four times daily for prophylaxis
Extended release form: 20 to 40mg 2 - 3 times daily.
Home Delivery for Isosorbide Dinitrate in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including isosorbide dinitrate.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for isosorbide dinitrate and other medicines and health products. Home delivery services for isosorbide dinitrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take isosorbide dinitrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for isosorbide dinitrate before they complete the sale. You can get this information while placing the order for isosorbide dinitrate with the pharmacy.
Isosorbide Dinitrate is a generic medicine name and there are several brands available for it. Some of the brands for isosorbide dinitrate might be better known than isosorbide dinitrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have isosorbide dinitrate in stock, you can ask for one of the branded alternatives for isosorbide dinitrate.