Distribution: Widely distributed in a protein bound form and crosses the placental barrier.
Metabolism: Metabolized in the liver by hydroxylation in to inactive metabolites.
Excretion: Excreted through urine. Onset of action: 6 to 12hours.
3. Gastrointestinal disturbances
8. Hypersensitivity reactions
11. Reversible alopecia
12. Liver diseases
2. Bleeding disorders
3. Ulceration of gastrointestinal tract
4. In sub acute bacterial endocarditis
5. Severe hypertension
6. Increased capillary permeability
7. Cerebrovascular haemorrhage
8. Recent eye brain or spinal cord surgery
12. Lumbar puncture
13. Vitamin K deficiency
14. Renal impairment
15. Hepatic impairment
Use with caution in following conditions:
1. Hepatic diseases
2. Renal diseases
3. Gastrointestinal tract disorders
5. Heart failure
6. Severe diabetes
7. Infectious diseases
8. Recent surgery
9. Other risks of haemorrhage
2. Pulmonary embolism
3. Transient ischemic attack
4. Atrial fibrillation
5. Rheumatic heart disease
6. Deep vein thrombosis
Drugs that increase the anticoagulant effect of warfarin by inhibition of hepatic metabolism: Amiodarone, chloramphenicol, Ifosamide, Cimetidine, Lovastatin Metronidazole, Omeprazole, Phenylbutazone, Propafenone, Quinine, Quinidine, sulphamethoxazole, trimethoprim, sulfinpyrazone.
Drugs that enhance efficacy of warfarin by displacement from binding sites: Chloral hydrate, Loop diuretics, Nalidixic acid.
Drugs that enhance anticoagulant effects of warfarin due to interference with Vit. K: Aminoglycosides, Mineral oil, tetracyline, Vit. E.
Drugs that enhance efficacy of warfarin due to effects on platelet function: Cephalosporins, Diflusinal, NSAIDs, Penicillins, salicylates.
Drugs that decrease anticoagulant effect of warfarin by unknown mechanism: Vitamin C, Griseofulvin, Sucralfate, Trazodone, Dicloxacillin, Nafcillin.
Drugs that decrease the anticoagulant effects of warfarin due to induction of the hepatic microsomal enzymes: Aminoglutethimide, Barbiturates, Carbamazepine, Rifampicin, Glutethimide, Etretinate.
Drugs that decrease the anticoagulant effect of warfarin due to various mechanisms: cholestyramine, oral contraceptives, estrogens, thiopurines, Spironolacetone, Vit.K, thiazide diuretics.
Start with 5mg daily. Then increases the dosage up to 15mg; based on prothrombin time and international normalized ratio.
Maintenance dosage: 2 to 10mg daily.
Home Delivery for Warfarin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including warfarin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for warfarin and other medicines and health products. Home delivery services for warfarin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take warfarin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for warfarin before they complete the sale. You can get this information while placing the order for warfarin with the pharmacy.
Warfarin is a generic medicine name and there are several brands available for it. Some of the brands for warfarin might be better known than warfarin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have warfarin in stock, you can ask for one of the branded alternatives for warfarin.