Mannitol 20% Pharmacology

Mannitol 20%

About Mannitol 20%
A polyol(sugar alcohol),low molecular weight non electrolyte, osmotic diuretic, Genitourinary Irrigant.
Mechanism of Action of Mannitol 20%
It is a non electrolyte of low molecular weight which limit the tubular water and electrolyte reabsorption in a variety of ways such as: - 1. Expanding extra cellular fluid volume and increase glomerular filtration rate and inhibits renin release. 2. Increases renal blood flow especially to the medulla hence medullary hyper tonicity is reduced and corticomedullary osmotic gradient is dissipated and thus passive salt reabsorption is reduced. 3. Retains water isoosmotically in proximal tubule and thus dilutes luminal fluid which opposes sodium chloride reabsorption. 4. Inhibits transport process in the thick ascending loop of Henle which ultimately leads to diuresis and enhanced excretion of all cations and anions. It also decongestant the eye by osmotic action.
Pharmacokinets of Mannitol 20%
Absorption: Not absorbed from gastrointestinal tract; should be administered intravenously.
Distribution: Distributed extra cellularly.
Metabolism: Metabolized minimally to glycogen in the liver.
Excretion: Excreted unchanged in urine.
Onset of Action for Mannitol 20%
15 to 60 minutes
Duration of Action for Mannitol 20%
3 to 8 hours
Half Life of Mannitol 20%
100 minutes
Side Effects of Mannitol 20%
1. Pulmonary congestion
2. Electrolyte imbalance
3. Acidosis
4. Dry mouth
5. Dehydration
6. Nausea
7. Vomiting
8. Thirst
9. Marked diuresis
10. Headache
11. Blurred vision
12. Fever
13. Chest pain
14. Infection and thrombophlebitis at site of injection
15. Ototoxicity

Contra-indications of Mannitol 20%
1. Hypersensitivity to the drug
2. Renal impairment
3. Anuria
4. Pulmonary congestion
5. Pulmonary oedema
6. Heart failure
7. Dehydration
8. Intracranial bleeding

Special Precautions while taking Mannitol 20%
1. Pulmonary congestion
2. Heart failure
3. Rapid I.V. administration

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Mannitol 20%
1. Oliguria
2. Acute renal failure
3. Oedema
4. Ascites
5. To reduce intraocular pressure
6. To monitor kidney function.
7. Diuresis in drug intoxication

Interactions for Mannitol 20%
Typical Dosage for Mannitol 20%
Adults: 50 to 200gm/day
Children: 0.2 to 2gm/kg/day

Schedule of Mannitol 20%
Storage Requirements for Mannitol 20%
Store at controlled room temperature at a range of 15 to 30 degree C and protect from freezing. Keep out of reach of children.
Effects of Missed Dosage of Mannitol 20%
The doctor should be informed immediately if a dose is missed.
Effects of Overdose of Mannitol 20%
Treatment is supportive and symptomatic. Discontinue the infusion and institute appropriate therapeutic counter measures. Haemodialysis remove Mannitol.

Home Delivery for Mannitol 20% in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mannitol 20%.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mannitol 20% and other medicines and health products. Home delivery services for mannitol 20% may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mannitol 20% only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mannitol 20% before they complete the sale. You can get this information while placing the order for mannitol 20% with the pharmacy.

Mannitol 20% is a generic medicine name and there are several brands available for it. Some of the brands for mannitol 20% might be better known than mannitol 20% itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mannitol 20% in stock, you can ask for one of the branded alternatives for mannitol 20%.