Cinnarizine Pharmacology


About Cinnarizine
Piperazines derivative, Antihistamine, Antivertigo.
Mechanism of Action of Cinnarizine
Cinnarizine is a specific competitive H1 receptor antagonist. It suppresses the vestibular end organ receptors and thus inhibits the activation of central cholinergic receptors. Cinnarizine inhibits contractions of vascular smooth muscles by inhibiting the calcium channels preferably in the arterial smooth muscle.
Pharmacokinets of Cinnarizine
Absorption: It is rapidly absorbed after oral administration. Distribution: It is widely distributed in the body in protein bound form. Excretion: Excreted mainly in faeces and also in urine
Onset of Action for Cinnarizine
With in 30 minutes
Duration of Action for Cinnarizine
Up to 8 hours
Half Life of Cinnarizine
3. 65 hours
Side Effects of Cinnarizine
6.Abdominal pain
7.Weight gain
10.Dry mouth.
Contra-indications of Cinnarizine
1.Hypersensitivity to Cinnarizine
2.Parkinson`s diseas
Special Precautions while taking Cinnarizine
2.Use caution while driving, operating machine or performing any hazardous activities
3.Avoid alcohol
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Cinnarizine
1.Motion sickness
2.Vertigo and other vestibular disturbances
3.Vomiting in Meniere`s disease
4.Treatment of vascular disorders (peripheral & Cerebrovascular)
Interactions for Cinnarizine
Alcohol & CNS depressants: Action enhanced.
Domperidone: Enhances efficacy of cinnarizine.
Typical Dosage for Cinnarizine
Motion sickness: 30 mg to be taken 2 hour before beginning the journey and if necessary dose can be repeated every 8 hours
Vertigo and other vestibular disturbances, vomiting in Meniere`s disease: 90 mg / day in 3 divided doses
Treatment of vascular disorders (peripheral & cerebrovascular): 75 mg 1-3 times daily.
Children 5 - 12 years:
Motion sickness: 15 mg to be taken 2 hour before beginning the journey and if necessary dose can be repeated every 8 hours
Vertigo and other vestibular disturbances, vomiting in Meniere`s disease: 45mg / day in 3 divided doses.
Schedule of Cinnarizine
Storage Requirements for Cinnarizine
Store below 25 degree C.Protect from light and moisture.
Effects of Missed Dosage of Cinnarizine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Cinnarizine
Give supportive measures and symptomatic treatment.

Home Delivery for Cinnarizine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cinnarizine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cinnarizine and other medicines and health products. Home delivery services for cinnarizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cinnarizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cinnarizine before they complete the sale. You can get this information while placing the order for cinnarizine with the pharmacy.

Cinnarizine is a generic medicine name and there are several brands available for it. Some of the brands for cinnarizine might be better known than cinnarizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cinnarizine in stock, you can ask for one of the branded alternatives for cinnarizine.