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- Pharmacology For Simvastatin + Nicotinic acid
Simvastatin + Nicotinic acid Pharmacology
Simvastatin + Nicotinic acid
About Simvastatin + Nicotinic acidN/AMechanism of Action of Simvastatin + Nicotinic acidN/APharmacokinets of Simvastatin + Nicotinic acidN/AOnset of Action for Simvastatin + Nicotinic acidN/ADuration of Action for Simvastatin + Nicotinic acidN/AHalf Life of Simvastatin + Nicotinic acidN/ASide Effects of Simvastatin + Nicotinic acidN/AContra-indications of Simvastatin + Nicotinic acidN/ASpecial Precautions while taking Simvastatin + Nicotinic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Simvastatin + Nicotinic acidN/AInteractions for Simvastatin + Nicotinic acidN/ATypical Dosage for Simvastatin + Nicotinic acidN/ASchedule of Simvastatin + Nicotinic acidN/AStorage Requirements for Simvastatin + Nicotinic acidN/AEffects of Missed Dosage of Simvastatin + Nicotinic acidN/AEffects of Overdose of Simvastatin + Nicotinic acidN/ASimvastatin
About SimvastatinStatins, HMG-CoA reductase inhibitor, A hypolipidemic agent.Mechanism of Action of SimvastatinIt is a precursor lactone converted in to active form in the body which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It increases high density lipoprotein (HDL) levels than other statins.Pharmacokinets of SimvastatinAbsorption: Readily absorbed orally but extensive fist pass hepatic metabolism limits bioavailability, Distribution: Distributed mainly to liver in a highly protein bound form and less than 5%of an oral dose reaches systemic circulation, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.Onset of Action for SimvastatinSignificant response seen after 1 to 2 weeks maximum therapeutic response seen after 4 to 6 weeks.Duration of Action for SimvastatinN/AHalf Life of Simvastatin3 hoursSide Effects of Simvastatin1.Headache
2.Dizziness
3.Abdominal discomfort
4.Heart burn
5.Abdominal pain
6.Nausea
7.Dyspepsia
8.Flatulence
9.Constipation
10.Blurred vision
11.Abnormal liver function tests
12.Rash
13.Pruritus
14.Fatigue
15.Myopathy
16. Upper respiratory tract infections
Contra-indications of Simvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Simvastatin1.Renal impairment
2.History of liver diseases
3.Alcoholics
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Simvastatin1.Hypercholesterolemia(types IIa, IIb)
2.Hypercholesterolemia along with hypertriglyceridemia)
Interactions for SimvastatinCyclosporine, erythromycin, niacin, gemfibrozil: Severe myopathy or rhabdomyolysis.
Propranolol: Decrease in antihyperlipidaemic activity.
Itraconazole: Plasma levels of lovastatin increased 20-fold.
Warfarin: Anticoagulant effect increased, chances of bleeding.Typical Dosage for SimvastatinOral:
Starts with 5 to 10mg once daily; with evening meals. Increased if required based on patients response at every four weeks.
Maximum dose: 40mg
Schedule of SimvastatinHStorage Requirements for SimvastatinStore at room temperature at a range of 15 to 25 degree C.Effects of Missed Dosage of SimvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of SimvastatinProvide supportive care and symptomatic treatment.Nicotinic Acid
About Nicotinic AcidN/AMechanism of Action of Nicotinic AcidNiacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.Pharmacokinets of Nicotinic AcidAbsorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.Onset of Action for Nicotinic AcidN/ADuration of Action for Nicotinic AcidN/AHalf Life of Nicotinic AcidN/ASide Effects of Nicotinic Acid1. Flushing
2. Activation of peptic ulcer
3. Nausea
4. Vomiting
5. Diarrhoea
6. Headache
7. Rashes
8. Pruritus
9. Hypotension
10. Arrhythmias
11. Hepatic impairment
Contra-indications of Nicotinic Acid1. Hypersensitivity to the drug
2. Hepatic impairment
3. Peptic ulcer
4. Severe hypotension
5. Arterial haemorrhage
Special Precautions while taking Nicotinic Acid1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
6.When use along with Statins reduces the dosage of StatinsPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Nicotinic Acid1. Pellagra
2. Niacin deficiency
3. Hartnup disease
4. Hyperlipidaemia (only nicotinic acid
5. Peripheral vascular diseases (only nicotinic acid)Interactions for Nicotinic AcidN/ATypical Dosage for Nicotinic AcidOral:
Peripheral vascular diseases: 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia: 1.5 to 6g daily in two to four divided doses with or after meals.
Schedule of Nicotinic AcidC1Storage Requirements for Nicotinic AcidStore at controlled room temperature at a range of 15 to 30 degree CEffects of Missed Dosage of Nicotinic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Nicotinic AcidProvide supportive measures and symptomatic treatmentHome Delivery for Simvastatin + Nicotinic acid in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for simvastatin + nicotinic acid and other medicines and health products. Home delivery services for simvastatin + nicotinic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Simvastatin + Nicotinic acid is a generic medicine name and there are several brands available for it. Some of the brands for simvastatin + nicotinic acid might be better known than simvastatin + nicotinic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have simvastatin + nicotinic acid in stock, you can ask for one of the branded alternatives for simvastatin + nicotinic acid.
