Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation in psychotic illness. Zuclopenthixol blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness.
Distribution: It is distributed in protein bound form
Metabolism: Zuclopenthixol undergoes metabolism in the liver by sulfoxidation, N-dealkylation and by glucuronic acid conjugation.
Excretion: Zuclopenthixol is excreted mainly in feces and small amount about 10% excreted in the urine.
2. Mood changes
9. Dry mouth
10. Blurred vision
11. Irregular blood pressure
14. Tardive dyskinesia
15. Skin rashes
17. Weight gain or weight loss
18. Changes in menstruation
19. Muscle rigidity
20. Altered consciousness
21. Cardiac arrhythmias
23. Elevated creatinine phosphokinase
25. Abnormal face and body movements
27. Uncontrollable movements of the tongue face and jaw
2. Acute alcohol, Barbiturate or opiate intoxication
3. Comatose states
4. Brain damage
5. Circulatory collapse
6. Blood dyscrasias
2. Severe liver disease
3. Heart diseases
5. Parkinson`s disease
6. Do not drink alcohol
7. Breathing problems
8. Not to be used for more than 14 days
9. Narrow angle glaucoma
10. Breast cancer
11. Pituitary tumors
12. Driving vehicle and operating machines and other works which require mental alertness
NEONATES : Contraindicated
3. Psychotic illness
Guanethidine: It reduces antihypertensive effect of Guanethidine
Tricyclic antidepressants, Neuroleptics: Mutually inhibit the metabolism of each other.
Levodopa, Adrenergic drug: Zuclopenthixol reduce the effect of these drug
Metoclopramide, Piperazine: Concomitant use increase the risk of extra pyramidal symptoms
Initial dose: 20 - 30 mg / day and dose can be increased to 150 mg / day if needed.
Maintenance dose: 20 - 50 mg / day
Intramuscular : 50 to 150 mg as IM injection and repeat the dose if needed after 2 - 3 days. Some patients need an additional injection 1 or 2 days after the first injection.
Zuclopenthixol acetate is not intended for long-term use, and the duration of treatment should not exceed 2 weeks. The maximum cumulative dosage should not exceed 400 mg, and the number of injections should not exceed 4.
The usual maintenance dose is 150 to 300 mg every 2 to 4 weeks.
Home Delivery for Zuclopenthixol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including zuclopenthixol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for zuclopenthixol and other medicines and health products. Home delivery services for zuclopenthixol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take zuclopenthixol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for zuclopenthixol before they complete the sale. You can get this information while placing the order for zuclopenthixol with the pharmacy.
Zuclopenthixol is a generic medicine name and there are several brands available for it. Some of the brands for zuclopenthixol might be better known than zuclopenthixol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have zuclopenthixol in stock, you can ask for one of the branded alternatives for zuclopenthixol.