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- Pharmacology For Entacapone
EntacaponeAbout EntacaponeCOMT Inhibitor, Systemic Anti-Parkinson`s Agent.Mechanism of Action of EntacaponeEntacapone is a peripherally acting Catechol O-methyl transferase (COMT) inhibitor. Entacapone block the O- methylation of Levodopa and increases the fraction of the drug available for delivery to the brain. This will result in increased concentration of dopamine and is useful in Parkinsonism.Pharmacokinets of EntacaponeAbsorption: Entacapone is rapidly absorbed after oral administration and the bioavailability is only 35%. Distribution: It is distributed in the body in protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: It is excreted mainly in faeces and only a small amount in urine.Onset of Action for Entacapone10 - 20 minutesDuration of Action for Entacapone2 hoursHalf Life of Entacapone3 - 5 hoursSide Effects of Entacapone1.Nausea
Contra-indications of Entacapone1.Hypersensitivity to EntacaponeSpecial Precautions while taking Entacapone1.Renal impairment
3.Patient on monoamine oxidase inhibitor therapy
4.Use caution when driving vehicle, operating machine or involving in any hazardous activities
6.Slowly withdraw the drug with caution
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated.
NEONATES: contraindicatedIndications for Entacapone1. Adjunct to Levodopa or Carbidopa for the treatment of idiopathic Parkinson`s disease
Interactions for EntacaponeNo interaction of entacapone with carbidopa has been observed with the recommended treatment schedule. The experience of the clinical use of entacapone with several drugs, including MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine, maprotiline and venlafaxine, and medicinal products that are metabolised by COMT is limited.
Typical Dosage for EntacaponeAdult: 200 mg with Carbidopa or Levodopa
Maximum daily dose: 1600 mg / day
Schedule of EntacaponeN/AStorage Requirements for EntacaponeStore at 15 - 30 degree C. Protect from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of EntacaponeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of EntacaponeGive supportive measures and symptomatic treatment. Gastric lavage can be done to increase the elimination of the drug. Activated charcoal is given to reduce the absorption of the drug.
Home Delivery for Entacapone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including entacapone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for entacapone and other medicines and health products. Home delivery services for entacapone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take entacapone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for entacapone before they complete the sale. You can get this information while placing the order for entacapone with the pharmacy.
Entacapone is a generic medicine name and there are several brands available for it. Some of the brands for entacapone might be better known than entacapone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have entacapone in stock, you can ask for one of the branded alternatives for entacapone.