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- Pharmacology For Doxycycline + Ornidazole
Doxycycline + Ornidazole Pharmacology
Doxycycline + Ornidazole
About Doxycycline + OrnidazoleN/AMechanism of Action of Doxycycline + OrnidazoleN/APharmacokinets of Doxycycline + OrnidazoleN/AOnset of Action for Doxycycline + OrnidazoleN/ADuration of Action for Doxycycline + OrnidazoleN/AHalf Life of Doxycycline + OrnidazoleN/ASide Effects of Doxycycline + OrnidazoleN/AContra-indications of Doxycycline + OrnidazoleN/ASpecial Precautions while taking Doxycycline + OrnidazoleN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Doxycycline + OrnidazoleN/AInteractions for Doxycycline + OrnidazoleN/ATypical Dosage for Doxycycline + OrnidazoleN/ASchedule of Doxycycline + OrnidazoleN/AStorage Requirements for Doxycycline + OrnidazoleN/AEffects of Missed Dosage of Doxycycline + OrnidazoleN/AEffects of Overdose of Doxycycline + OrnidazoleN/ADoxycycline
About DoxycyclineTetracycline Derivative, Antibiotic.Mechanism of Action of DoxycyclineDoxycycline is a broad spectrum antibiotic which acts against both gram positive and gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein and by passive diffusion & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals).Doxycycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca &Mg and inhibits functioning of various enzymes & ribosome.
Doxycycline is used in some areas for the treatment of Chloroquine-resistant falciparum malaria
Pharmacokinets of DoxycyclineAbsorption: Orally well absorbed, food has not much effect on absorption.
Distribution: Widely distributed; shows protein- binding.
Metabolism: Not substantially metabolized inside the body.
Excretion: Primarily excreted through faeces. Some drug is present in breast milk & a portion is excreted through urine.
Onset of Action for Doxycycline4 to 12 hoursDuration of Action for Doxycycline24 hoursHalf Life of Doxycycline18 to 24 hoursSide Effects of Doxycycline1. Photo toxicity
2. Intracranial hypertension
3. Dysphagia
4. Nausea
5. Vomiting
6. Epigastric distress
7. Super infection
8. Skin rashes
9. Pericarditis
10. Neutropenia
11. Elevated liver enzymes
12. Discoloration of teeth
13. Esophageal ulceration
14. Glossitis
15. Thrombocytopenia
16. Retardation of bone growthContra-indications of Doxycycline1. Hypersensitivity to the drug or other tetracyclinesSpecial Precautions while taking Doxycycline1.Renal impairment
2.Hepatic impairment
3.Sun exposure may leads to photo toxicity.
4.Alcohol uptake may decrease antibiotic effect.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : ContraindicatedIndications for Doxycycline1. Syphilis
2. Lympho granuloma veneram
3. Typhus fever
4. Respiratory tract infections
5. Prophylaxis of malaria
6. Urinogenital tract infections
7. Trachoma
8. Pelvic inflammatory diseases
9. Acne
10. Diarrhoea
11. Gonorrhea in penicillin allergic individuals
12. Pneumonia
13. Rickettsial infections
14. Urethritis
15. AnthraxInteractions for DoxycyclineAntacids (aluminium, calcium zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of tetracyclines thus reducing its efficacy.
Anticoagulants: Increase the hypothrombinemic effects of anticoagulants.
Cimetidine: Decreases GI absorption leading to decreased efficacy of tetracyclines.
Digoxin: Increased serum levels leading to digoxin toxicity.
Methoxyflurane: Nephrotoxic effects of both increased.
Oral contraceptives: Breakthrough bleeding, pregnancy due to decreased efficacy.
Penicillins: Efficacy reduced.
Food: Dairy products decrease efficacy of tetracyclines.
Lab Tests: Bacteriosuppressive levels of Demeclocycline persist in both urine and blood for several days after cessation of therapy interfering with culture studies.
Typical Dosage for DoxycyclineAdults: 0.2gm initial dose followed by 0.1gm once daily.
In severe infections: 0.1gm 12 hourly up to 10 days.
Malaria: 200 mg daily for at least 7 days after treatment with quinine.
Malaria prophylaxis: Doxycycline 100 mg daily.
Anthrax: 200 mg / day in 2 divided doses
Acne: 100mg/day Or 50mg twice daily.
Urethritis: 100 mg twice a day for 7 days
Children (above 8 years of age): 3 to 5 mg/kg/day in two divided doses.
Schedule of DoxycyclineHStorage Requirements for DoxycyclineStore in a cool place.Effects of Missed Dosage of DoxycyclineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of DoxycyclineTreatment is supportive & symptomatic. Drug can be removed by gastric lavage.Ornidazole
About OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. Home Delivery for Doxycycline + Ornidazole in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including doxycycline + ornidazole.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for doxycycline + ornidazole and other medicines and health products. Home delivery services for doxycycline + ornidazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take doxycycline + ornidazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for doxycycline + ornidazole before they complete the sale. You can get this information while placing the order for doxycycline + ornidazole with the pharmacy.
Doxycycline + Ornidazole is a generic medicine name and there are several brands available for it. Some of the brands for doxycycline + ornidazole might be better known than doxycycline + ornidazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxycycline + ornidazole in stock, you can ask for one of the branded alternatives for doxycycline + ornidazole.
