Duloxetine Pharmacology


About Duloxetine
A serotonin-norepinephrine reuptake inhibitor,Thiophene derivative, Antidepressant.
Mechanism of Action of Duloxetine
Duloxetine preferentially inhibits the re-uptake of Noradrenaline and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitter Serotonin in the synaptic cleft and produces antidepressant effect
Pharmacokinets of Duloxetine
Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body in protein bound form. Metabolism: Duloxetine is extensively metabolised in the liver. Excretion: Excreted mainly through urine and small amount excreted through urine.
Onset of Action for Duloxetine
Duration of Action for Duloxetine
Half Life of Duloxetine
12 hours
Side Effects of Duloxetine
4.Dry mouth
6.Decreased appetite
7.Decreased weight
12.Sweating increased
13.Hot flushes
14.Blurred Vision
17.Ejaculatory dysfunction

Contra-indications of Duloxetine
1.Hypersensitivity to Duloxetine
2.Patient on Monoamine Oxidase Inhibitors therapy
3.Uncontrolled Narrow-Angle Glaucoma
4.Severe hepatic impairment
Special Precautions while taking Duloxetine
1.Bipolar affective disorder
2.History of mania
4.Heart disease
5.People with bleeding tendencies
Pregnancy Related Information
Old Age Related Information
use with caution
Breast Feeding Related Information
Children Related Information
Indications for Duloxetine
1. Major depressive disorder
2. Diabetic Peripheral Neuropathic Pain
3. Generalised anxiety disorder
Interactions for Duloxetine
Typical Dosage for Duloxetine
Major Depressive Disorder: 20 - 60mg / day in 2 divided doses
Diabetic Peripheral Neuropathic Pain:60 mg/day
Generalized Anxiety Disorder: 60 mg/ day
Schedule of Duloxetine
Storage Requirements for Duloxetine
Store at 15 - 25 degree C. Keep out of the reach of children.
Effects of Missed Dosage of Duloxetine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Duloxetine
Give supportive measures and symptomatic treatment. Gastric lavage can be done to eliminate the drug from the body. Charcoal can be given to reduce the absorption of the drug.

Home Delivery for Duloxetine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including duloxetine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for duloxetine and other medicines and health products. Home delivery services for duloxetine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take duloxetine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for duloxetine before they complete the sale. You can get this information while placing the order for duloxetine with the pharmacy.

Duloxetine is a generic medicine name and there are several brands available for it. Some of the brands for duloxetine might be better known than duloxetine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have duloxetine in stock, you can ask for one of the branded alternatives for duloxetine.